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Oxman MN, Levin MJ, Johnson MS, Schmader KE, Straus SE, Gelb LD, et al. Une étude pharmacocinétique à doses multiples effectuée chez des sujets présentant une cirrhose légère et stable a démontré un allongement de la demi-vie d'élimination et une augmentation d'un facteur 3 de l'ASC et de la C max par rapport aux sujets normaux!